Starting with the Haber-Bosch ammonia synthesis, the chemical industries delivered a broad portfolio of fertilizers, crop and yield protecting agents, novel breeds with new and traits and efficient logistic options for farming. But, the continuous increase of world´s population, the climate change, and the environmental impact of todays industrialized farming are a severe challenges for the future. In addition, public opinion has changed and asks for innovative solutions to solve tomorrows problems. With a focus of the synergistic employment of plant microbiome research, molecular biology, new generation sequencing (NGS), bioinformatics and modern algorithms we can develop a vision beyond Chemical Crop Protection.